Endocrine Abstracts

Aim: Evaluate the data of anamnesis, clinical-laboratory parameters, magnetic resonance imaging (MRI) findings, response to treatment in children with hyperprolactinemia (HProlact).Methods: We analyzed retrospectively 16 patients in the endocrinological department of University hospital (Minsk) with HProlact over 2004–2012 years. Boys (B) 6 (37.5%) (stage on Tanner 1 – 1 (17%); stage 2–3 – 3 (50%), stage 4 – 2 (33%), age at diagn...

Aim: To assess changes of metabolic status in children with pituitary insufficiency.Methods: We examined retrospectively 28 children with pituitary insufficiency in the Endocrinological department of University hospital (Minsk) over 2001–2013 years. Group 1 (G1) - children with multiple acquired pituitary insufficiency (MAPI) after brain tumors treatment (11 children (73.3%) underwent surgical, 4 (26.7%) - combined treatment: surgical and radiation ...

Objective: To study feeding habits in children of different ages with alimentary obesity compared with normative values.Methods: We compared 3 days food diaries of 98 children with alimentary obesity observed in the Endocrinology Department of University Hospital (Minsk) with nutritional standards of healthy children recommended by Belarusian National Center for Hygiene, Epidemiology and Public Health – control (K). Patients were divided into three ...

Aim: To identify perinatal risk factors of the development of simple obesity in adolescence.Methods: We analysed retrospectively 327 histories of development in pubertal children, with the division into two groups: group 1 – 158 obese children (age 14.6±2 years, BMI 33.4±5 kg/m2), group 2 – 169 normal-weight patients (age 12.6±2.2 (P=0.2); BMI 20.5±1.2 kg/m2 (P<0.05)) from the Univ...

Aim: To evaluate bone mineral density (BMD) and its relationship with calcium (Ca) and phosphorus (P) metabolism in children with obesity.Methods: We examined 105 children in the University Hospital (Minsk) from 2011 to 2015 yrs. Their anthropometric parameters (height, weight, BMI) were determined. Body composition with evaluating of mineral component were made by dual energy X-ray absorptiometry with the calculation of feet, hands, spine, ribs, hips BM...

Objectives: Neurogenetical predictors of psychological disturbances in children with severe obesity.Methods: We examined 254 pubertal obese children: group1 (simple obesity) 187 children, 14.3±2.0 yrs, 30.4±2.8 kg/m2; group2 (severe obesity) 67 children, 14.7±2.1, 39.1±3.8. Control 80 children, 14.4±2.0 yrs, 19.7±1.7 kg/m2. Dopamine levels were determined. Genotyping was performed on polymorphic genes C...

Background: It is well known that many nuerohormonal and genetic factors influence on the developing of obesity in children. Serotoninergic system is determined to be one of the most important factors. Serotonin may induce lipogenesis or triacylglycerol synthesis in the liver and/or white adipose tissue.Aim: To establish interactions between serotoninergic system and metabolic parameters in obese children.Methods: We examined 280 c...

Objectives: The prevalence of diabetes mellitus type 1 (DM 1) had increased nowadays in children in Belarus. Psychological problems are one of side-effects of the disease.Aim: To determine the presence of psychological problems in children with DM 1.Methods: We examined 45 children (boys – 23, girls – 22) age 14.4±0.8 years, with DM 1 in University hospital (Minsk) in 2014–2015 years. All children underwent psyc...

Introduction: Autoimmune polyglandular syndrome type 1 (APS1) – severe disease that is rare in pediatric practice. Clinical sings of APS1 are quite diverse, new components may manifest at any age. Their timely diagnosis is critically important, some symptoms can threaten patient’s life. We present our own clinical observation of the APS1 course in siblings.Case report: A 10-year-old previously healthy boy presented with severe weakness, drowsin...

Background: The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D2 receptor binding (Thompson et al., 1997; Pohjalainen et al.,1998). Associations between Taq1A polymorphism DRD2/ANKK1 gene and reward sensitivity including compulsive overeating were reported (Propper et al., 2008; Davis et al., 2008). To study the association of DRD2/ANKK1 Taq1A polymorphism (rs1800497) with obesity we started g...